Hypnotic bodies.



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: UNITED snares Parana? @h l lfim- LAMBERT Canons, osnnnaom, MIGHIGAN.

HYPNOTIC BODIES,

No Drawing.

To all whom it may concern:

Be it known that I, LAMBERT Tnonr, a citizen. of the United States ofAmerica, residing at Detroit, in the county of l/Vayne and State ofMichigan, have invented certain new and useful Improvements in HypnotieBodies, of'which the following is a specification.

Myinvention relates to the production of a new series of bodies, andaims to provide a substance which, While possessing Wellpronouncedsedative and hypnotic PLOPQT- ties, is of very low toxicity.

1 have found that the series of compounds to which the general-name,alpha-bromoisovalerianylurethane, may be applied, is possessed ofWell-pronounced sedative and hypnoticproperties and is of very lowtoxicity.

The new series of compounds may be represented by the general formula:

wherein'l't stands for any alkyl or substituted allcyl group.

i on

the process may be carried out, for instance, as follows Two parts, byweight, of alpha-bromoisoalerianyl chlorid are mixed With one part, byWeight, of ethyl urethane (amidoformic ethyl ester),and the mixture thenheated in a suitable bath to a temperature of 100-120 C. for severalhours. When hydrogen chlorid ceases to be evolved, the product of thereaction, is cooled, and then recrystaL lized from dilute alcohol. Thenew substance, namely, alpha -bro1noisovalerianyl ethyl urethane, of theformula,

crystallizes in the form of colorless needles, melting at 114 C.

In an analogous or different manner otheralpha-bromoisomlerianylurethanes may be obtained.

What I claim as my invention is:

1. As new products, the alpha-bromoiso- *alerianylurethanes, beingcolorless, crystal- Specification of Letters Patent.

valerianylurethanes by the Patented Aug, or, Edit,

Application filed February 28, 1917. Serial No. 151,553.

I have found that the Compounds of the new series, namely, thealpha-bromoisovalerianylurethanes may be obtained. by the action ofalpha-broinoisovalerianyl chlorid upon urethanes. The compounds, thusobtained, hitherto unknown, are valuable for medicinal purposes assedatives and hypnotics.

The alpha ln-omoisovalerianylurethancs are colorless, crystallinecompounds, very slightly soluble in Water; more readily soluble inalcohol or ether; easily soluble in cold solutions of the causticallraiis, from x which solutions they are precipitated unchanged by theaddition of a mineral acid. hen boiled with a solution of a alkalinehydroxid the alpha-bromoisovalerianylurethanes are decomposed withevolution of ammonia, while the bromin remains in solution as analkaline bromid. The new compounds are possessed of a mildly bittertaste, and display sedative and hypnotic powers.

To prepare the said new alphabromoisd method wherein the chemical changeinvolved may be expressed by the equation:

ain--onco-'-Nn-oooR- 19:01,

line compounds, very slightly soluble in water; more readily soluble inalcohol or ether; easily soluble in cold solutions of the, causticalkalis, -from which. solutions they" are precipitated unchanged by theaddition of a mineral acid; decomposed when boiled a mildly bittertaste, and displaying sedative and hypnotic powers.

In testimony whereof I aiiix my signature.

LAMBERT THORP.

35 As a new product, alpha-bromoisova

